Pub. Date : 2014 Sep
PMID : 25272939
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome. | Losartan | NLR family, pyrin domain containing 3 | Mus musculus |
| 2 | To further elucidate the molecular mechanism underlying the anti-IL-1beta property of losartan, we studied the LPS+ATP-induced activation of NALP3 inflammasome which controls the muturation and secretion of IL-1beta. | Losartan | NLR family, pyrin domain containing 3 | Mus musculus |
| 3 | The macrophages co-cultured with losartan showed low production of IL-1beta (3907.50 +/- 143.61; P < 0.05) and low production of NALP3, caspase-1mRNA (29.82 +/- 6.92; 1.12 +/- 0.05, P < 0.05 for both). | Losartan | NLR family, pyrin domain containing 3 | Mus musculus |