Pub. Date : 2014 Sep
PMID : 25272939
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 2 | To further elucidate the molecular mechanism underlying the anti-IL-1beta property of losartan, we studied the LPS+ATP-induced activation of NALP3 inflammasome which controls the muturation and secretion of IL-1beta. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 3 | METHODS: LPS and ATP were used to stimulate the release of IL-1beta from thioglycollate-elicited macrophages from BALB/c mice. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 4 | RESULTS: In cultured thioglycollate-elicited macrophages, we observed that LPS + ATP greatly enhanced IL-1 beta secretion (6938.00 +/- 83.45; P < 0.05) and the mRNA levels of NALP3, caspase-1 which are two main components of NALP3 inflammasome (60.88 +/- 8.28; 1.31 +/- 0.04, P < 0.05 for both). | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 5 | Losartan is able to suppress the LPS + ATP-induced production of IL-1beta protein. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |