Pub. Date : 2015 Feb 1
PMID : 25264713
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Peroxiredoxin-2 (Prx-2) is a primary RBC antioxidant that limits hydrogen peroxide (H2O2)-mediated toxicity. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 2 | Peroxiredoxin-2 (Prx-2) is a primary RBC antioxidant that limits hydrogen peroxide (H2O2)-mediated toxicity. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 3 | Peroxiredoxin-2 (Prx-2) is a primary RBC antioxidant that limits hydrogen peroxide (H2O2)-mediated toxicity. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 4 | Peroxiredoxin-2 (Prx-2) is a primary RBC antioxidant that limits hydrogen peroxide (H2O2)-mediated toxicity. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 5 | RESULTS: Basal and H2O2-induced Prx-2 activity was measured in RBCs (stored for 7-35 days). | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 6 | Basal Prx-2 thiol oxidation increased with RBC age, whereas H2O2-dependent formation of dimeric Prx-2 was similar. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 7 | However, reduction of Prx-2 dimers to monomers became progressively slower with RBC storage, which was associated with increased H2O2-induced hemolysis. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 8 | Specifically, Prx-2 recycling was blunted in beta93Ala RBC, which was reversed by carbon monoxide-treatment, suggesting that heme autoxidation-derived H2O2 maintains Prx-2 in the oxidized form in these cells. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 9 | Specifically, Prx-2 recycling was blunted in beta93Ala RBC, which was reversed by carbon monoxide-treatment, suggesting that heme autoxidation-derived H2O2 maintains Prx-2 in the oxidized form in these cells. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |