Title : Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.

Pub. Date : 2014 Dec 18

PMID : 25261337






1 Functional Relationships(s)
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1 The uptake activity was measured in HEK293 cell-lines stably overexpressing OATP1B1(*)1a, OATP1B3 or OATP2B1, the major transporters involved in human hepatic uptake of rosuvastatin, or expressing OATP1B1(*)15, associated with reduced hepatic uptake of rosuvastatin. Rosuvastatin Calcium solute carrier organic anion transporter family member 1B3 Homo sapiens