Pub. Date : 2015 Feb
PMID : 25258021
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of monoacylglycerol lipase reduces nicotine withdrawal. | Nicotine | monoglyceride lipase | Mus musculus |
| 2 | EXPERIMENTAL APPROACH: To evaluate the role of MAGL enzyme inhibition in nicotine withdrawal, we initially performed a genetic correlation approach using the BXD recombinant inbred mouse panel. | Nicotine | monoglyceride lipase | Mus musculus |
| 3 | MAGL-knockout mice also showed attenuated nicotine withdrawal. | Nicotine | monoglyceride lipase | Mus musculus |
| 4 | CONCLUSIONS AND IMPLICATIONS: Overall, our findings suggest that MAGL inhibition maybe a promising target for treatment of nicotine dependence. | Nicotine | monoglyceride lipase | Mus musculus |