Pub. Date : 2014 Nov
PMID : 25255717
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Fibrocytes did not affect ASMC proliferation and expression of TGF-beta1, eotaxin, alpha-SMA and MLCK; however, ASMC production of IL-8 and IL-6 was increased in the co-culture and transwell culture by FC. | asmc | interleukin 6 | Homo sapiens |
| 2 | ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6. | asmc | interleukin 6 | Homo sapiens |
| 3 | ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6. | asmc | interleukin 6 | Homo sapiens |
| 4 | Furthermore, siRNA silencing of NF-kappaB-p65 or ERK1/2 in transwell cultures of asthmatic ASMC with normal subject FC decreased IL-8 and IL-6 production. | asmc | interleukin 6 | Homo sapiens |
| 5 | CONCLUSIONS AND CLINICAL RELEVANCE: Fibrocytes promoted IL-8 and IL-6 production by ASMC, demonstrating a proinflammatory role for FC and a possible mechanism of the inflammatory phenotype in asthma. | asmc | interleukin 6 | Homo sapiens |