Title : Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling.

Pub. Date : 2014 Nov 24

PMID : 25255434






3 Functional Relationships(s)
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1 Some of these sulfonamides were 6-8 fold more potent than the reference drug acetazolamide (AZA, Ki = 5.7 nM)) against hCA XII showing subnanomolar activity. Acetazolamide carbonic anhydrase 12 Homo sapiens
2 Some of these sulfonamides were 6-8 fold more potent than the reference drug acetazolamide (AZA, Ki = 5.7 nM)) against hCA XII showing subnanomolar activity. Acetazolamide carbonic anhydrase 12 Homo sapiens
3 Docking of these sulfonamides with CA XII was performed and their binding modes were comparable with that of AZA. Acetazolamide carbonic anhydrase 12 Homo sapiens