Title : Presynaptic inhibitory effects of fluvoxamine, a selective serotonin reuptake inhibitor, on nociceptive excitatory synaptic transmission in spinal superficial dorsal horn neurons of adult mice.

Pub. Date : 2014

PMID : 25252797






2 Functional Relationships(s)
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1 Fluvoxamine (10 - 100 muM) concentration-dependently suppressed both monosynaptic A-fiber- and C-fiber-mediated EPSCs, which were attenuated by the selective 5-HT1A receptor antagonist WAY100635. Fluvoxamine 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
2 These results suggest that fluvoxamine reduces excitatory synaptic transmission from primary afferent fibers via presynaptic mechanisms involving 5-HT1A and/or 5-HT3 receptors, which may contribute to its analgesic effects. Fluvoxamine 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus