Title : Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis.

Pub. Date : 2014 Dec

PMID : 25251877






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis. Cyclophosphamide ATP binding cassette subfamily B member 1 Homo sapiens
2 Susceptibility of CD4(+) regulatory T (Treg) cells to the ABCB1-substrate cyclophosphamide (CPA) has been reported. Cyclophosphamide ATP binding cassette subfamily B member 1 Homo sapiens
3 Susceptibility of CD4(+) regulatory T (Treg) cells to the ABCB1-substrate cyclophosphamide (CPA) has been reported. Cyclophosphamide ATP binding cassette subfamily B member 1 Homo sapiens
4 In vitro, the ABCB1-substrate CPA was cytotoxic for Treg cells at a 100-fold lower dose than for nonregulatory counterparts, and, inversely, verapamil, an inhibitor of ABC transporters, increased CPA-toxicity in nonregulatory CD4(+) T cells but not Treg cells. Cyclophosphamide ATP binding cassette subfamily B member 1 Homo sapiens
5 In vitro, the ABCB1-substrate CPA was cytotoxic for Treg cells at a 100-fold lower dose than for nonregulatory counterparts, and, inversely, verapamil, an inhibitor of ABC transporters, increased CPA-toxicity in nonregulatory CD4(+) T cells but not Treg cells. Cyclophosphamide ATP binding cassette subfamily B member 1 Homo sapiens