Pub. Date : 2014 Dec
PMID : 25251877
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis. | Cyclophosphamide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Susceptibility of CD4(+) regulatory T (Treg) cells to the ABCB1-substrate cyclophosphamide (CPA) has been reported. | Cyclophosphamide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Susceptibility of CD4(+) regulatory T (Treg) cells to the ABCB1-substrate cyclophosphamide (CPA) has been reported. | Cyclophosphamide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | In vitro, the ABCB1-substrate CPA was cytotoxic for Treg cells at a 100-fold lower dose than for nonregulatory counterparts, and, inversely, verapamil, an inhibitor of ABC transporters, increased CPA-toxicity in nonregulatory CD4(+) T cells but not Treg cells. | Cyclophosphamide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | In vitro, the ABCB1-substrate CPA was cytotoxic for Treg cells at a 100-fold lower dose than for nonregulatory counterparts, and, inversely, verapamil, an inhibitor of ABC transporters, increased CPA-toxicity in nonregulatory CD4(+) T cells but not Treg cells. | Cyclophosphamide | ATP binding cassette subfamily B member 1 | Homo sapiens |