Title : Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression.

Pub. Date : 2014 Dec

PMID : 25245054






2 Functional Relationships(s)
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1 Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-kappaB-dependent pathway that reduces uPA and MMP-9 expression. Metformin mitogen-activated protein kinase 1 Homo sapiens
2 In conclusion, metformin inhibits the migration and invasion of HCC cells by suppressing the ERK/JNK-mediated NF-kappaB-dependent pathway, and thereby reducing uPA and MMP-9 expression. Metformin mitogen-activated protein kinase 1 Homo sapiens