Title : Mechanism of inhibition of estrogen biosynthesis by azole fungicides.

Pub. Date : 2014 Dec

PMID : 25243857






2 Functional Relationships(s)
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1 We interpret the inhibition mechanism in the context of the x-ray structure of aromatase-androstenedione complex. Androstenedione cytochrome P450 family 19 subfamily A member 1 Homo sapiens
2 The substrate-binding cavity at the heme-distal site closely compliments the structures of the natural substrate, androstenedione, and steroidal aromatase inhibitors. Androstenedione cytochrome P450 family 19 subfamily A member 1 Homo sapiens