Title : Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor.

Pub. Date : 2014 Sep 21

PMID : 25240937






3 Functional Relationships(s)
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1 Tumor-derived TGF-beta and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor. Dinoprostone epidermal growth factor receptor Homo sapiens
2 Conversely, production of transforming growth factor beta (TGF-beta) and prostaglandin E2 was increased by EGFR inhibition, indicating that these immunosuppressive molecules were involved in diminishing tumor recognition by T cells. Dinoprostone epidermal growth factor receptor Homo sapiens
3 CONCLUSIONS: Targeting TGF-beta and prostaglandin E2 may allow for improved outcomes for cancer patients treated with combination immunotherapy and EGFR inhibitors. Dinoprostone epidermal growth factor receptor Homo sapiens