Pub. Date : 2015 Jan
PMID : 25240575
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Impact of CYP3A4 and MDR1 gene (G2677T) polymorphisms on dose requirement of the cyclosporine in renal transplant Egyptian recipients. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Interindividual heterogeneity in expression of ABCB1 and CYP3A4 has been suspected to be one of the factors resulting in cyclosporine (CsA) pharmacokinetic variation. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Interindividual heterogeneity in expression of ABCB1 and CYP3A4 has been suspected to be one of the factors resulting in cyclosporine (CsA) pharmacokinetic variation. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | This study aimed to investigate the impact of inter-individual CYP3A4 rs4646437C>T and MDR1 G2677T/A polymorphisms on cyclosporine dose requirements among a sample of renal transplant Egyptian recipients. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Fifty adult Egyptian patients on CsA were genotyped for CYP3A4 rs4646437C>T and MDR1 G2677T/A and correlated with CsA dose requirement and dose-adjusted CsA (C0) blood levels at 3, 6, and 9 months post transplantation. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | Fifty adult Egyptian patients on CsA were genotyped for CYP3A4 rs4646437C>T and MDR1 G2677T/A and correlated with CsA dose requirement and dose-adjusted CsA (C0) blood levels at 3, 6, and 9 months post transplantation. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Genotyping of both CYP3A4 and MDR1 SNPs may be helpful in providing pre-transplant pharmacogenetic information to individualize CsA dosing. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |