Pub. Date : 2015 Mar
PMID : 25238698
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: AUC-B 0-4 and AUC-D 0-6 were significantly lower with insulin glulisine than with regular insulin (AUC-B 0-4: 3.3 +- 4.7 vs. 6.2 +- 5.4 x 10(2) mmol/L minute, respectively, P = .028; AUC-D 0-6: 1.8 +- 7.3 vs. 6.5 +- 6.2 x 10(2) mmol/L minute, respectively, P = .023). | glulisine | insulin | Homo sapiens |
| 2 | In contrast, AUC-L 0-6 was higher with insulin glulisine than with regular insulin (AUC-L 0-6: 7.6 +- 6.4 vs. 4.2 +- 8.7 x 10(2) mmol/L minute, respectively, P = .099), suggesting a prolonged hypoglycemic action of regular insulin after lunch. | glulisine | insulin | Homo sapiens |
| 3 | CONCLUSIONS: Insulin glulisine effectively suppressed postprandial hyperglycemia, whereas regular insulin caused a prolonged hypoglycemic action. | glulisine | insulin | Homo sapiens |
| 4 | These findings support the effectiveness and safety of insulin glulisine in patients with type 2 diabetes and severe renal insufficiency. | glulisine | insulin | Homo sapiens |