Pub. Date : 2014 Nov 15
PMID : 25231351
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of mTORC1 activation in acid-alpha-glucosidase-deficient cells and mice is ameliorated by leucine supplementation. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Treatment with the cell-permeable leucine analog L-leucyl-L-leucine methyl ester restored mTORC1 activation. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | In vivo, Pompe mice also displayed reduced basal and leucine-stimulated mTORC1 activation in skeletal muscle, whereas treatment with a combination of insulin and leucine normalized mTORC1 activation. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Chronic leucine feeding restored basal and leucine-stimulated mTORC1 activation, while partially protecting Pompe mice from developing kyphosis and the decline in muscle mass. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 5 | Chronic leucine feeding restored basal and leucine-stimulated mTORC1 activation, while partially protecting Pompe mice from developing kyphosis and the decline in muscle mass. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 6 | Moreover, mTORC1 stimulation by dietary leucine supplementation prevented some of the detrimental skeletal muscle dysfunction that occurs in the Pompe disease mouse model. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |