Title : Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: implication in a loss-of-function pathology.

Pub. Date : 2014 Sep 18

PMID : 25231079






1 Functional Relationships(s)
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1 We found that the aggregates formed by polyQ-expanded Atx3 sequester its interacting partners, such as P97/VCP and ubiquitin conjugates, into the protein inclusions through specific interactions both in vitro and in cells. polyglutamine valosin containing protein Homo sapiens