Title : Hemolysis-induced lethality involves inflammasome activation by heme.

Pub. Date : 2014 Sep 30

PMID : 25225402






1 Functional Relationships(s)
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1 The activation of NLRP3 by heme required spleen tyrosine kinase, NADPH oxidase-2, mitochondrial reactive oxygen species, and K(+) efflux, whereas it was independent of heme internalization, lysosomal damage, ATP release, the purinergic receptor P2X7, and cell death. Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens