Pub. Date : 2015 Feb
PMID : 25218038
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fluoxetine potentiation of methylphenidate-induced gene regulation in striatal output pathways: potential role for 5-HT1B receptor. | Methylphenidate | 5-hydroxytryptamine receptor 1B | Homo sapiens |
| 2 | A further study showed that the 5-HT1B receptor agonist CP94253 (3-10 mg/kg) mimics the fluoxetine potentiation of methylphenidate-induced gene regulation. | Methylphenidate | 5-hydroxytryptamine receptor 1B | Homo sapiens |
| 3 | Given that 5-HT1B receptors are known to facilitate addiction-related gene regulation and behavior, our results suggest that SSRIs may enhance the addiction liability of methylphenidate by increasing 5-HT1B receptor signaling. | Methylphenidate | 5-hydroxytryptamine receptor 1B | Homo sapiens |
| 4 | Given that 5-HT1B receptors are known to facilitate addiction-related gene regulation and behavior, our results suggest that SSRIs may enhance the addiction liability of methylphenidate by increasing 5-HT1B receptor signaling. | Methylphenidate | 5-hydroxytryptamine receptor 1B | Homo sapiens |