Title : JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2.

Pub. Date : 2014 Nov 6

PMID : 25217696






1 Functional Relationships(s)
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1 Normal hematopoietic cells showed elevated ROS levels through increased intracellular iron levels when treated with lipocalin-2, which led to p53 pathway activation, increased apoptosis, and decreased cellular proliferation. Iron tumor protein p53 Homo sapiens