Pub. Date : 2014 Nov
PMID : 25216715
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 2 | These effects of GM1 were abolished by Trk receptor tyrosine kinase inhibitor and diminished by MEK1/2, phosphoinositide 3-kinase and protein kinase C inhibitors. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 3 | GM1 was found to activate Trk receptor tyrosine kinase in PC12 cells. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 4 | Thus, the protective and metabolic effects of GM1 ganglioside on PC12 cells exposed to hydrogen peroxide appear to depend on the activation of Trk receptor tyrosine kinase and downstream activation of Akt and ERK1/2. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |