Title : Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells.

Pub. Date : 2014 Dec

PMID : 25214240






7 Functional Relationships(s)
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1 RESULTS: To better understand the apoptotic effect of EBR, we aimed to investigate the cellular responses in p53 null, PC3 prostate cancer cells. EBR tumor protein p53 Homo sapiens
2 We showed that EBR induced mitochondria-mediated and caspase-dependent apoptosis in wt and p53 stable transfected PC3 cells, which suggesting that EBR-induced apoptosis regardless of p53 expression. EBR tumor protein p53 Homo sapiens
3 We showed that EBR induced mitochondria-mediated and caspase-dependent apoptosis in wt and p53 stable transfected PC3 cells, which suggesting that EBR-induced apoptosis regardless of p53 expression. EBR tumor protein p53 Homo sapiens
4 Furthermore, EBR treatment was also induced apoptosis in both LNCaP(wt p53) and DU 145 (mt p53)cells, respectively. EBR tumor protein p53 Homo sapiens
5 Furthermore, EBR treatment was also induced apoptosis in both LNCaP(wt p53) and DU 145 (mt p53)cells, respectively. EBR tumor protein p53 Homo sapiens
6 These all findings verified that EBR-induced apoptosis regardless of p53 expression. EBR tumor protein p53 Homo sapiens
7 CONCLUSIONS: Therefore, we concluded that EBR-induced apoptosis was mainly related with PA catabolic pathway and independent from p53 expression. EBR tumor protein p53 Homo sapiens