Title : Key roles for tyrosine 10 in aβ-heme complexes and its relevance to oxidative stress.

Pub. Date : 2015 Mar 16

PMID : 25211009






2 Functional Relationships(s)
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1 Under oxidative (H2O2) and nitrative (H2O2/NaNO2) stress conditions, the Abeta40-heme complexes caused oxidation and nitration of the Abeta Tyr-10 residue through promoting peroxidase-like reactions, which were different from the classic inhibitive effect of heme on Abeta aggregation. Hydrogen Peroxide amyloid beta precursor protein Homo sapiens
2 Under oxidative (H2O2) and nitrative (H2O2/NaNO2) stress conditions, the Abeta40-heme complexes caused oxidation and nitration of the Abeta Tyr-10 residue through promoting peroxidase-like reactions, which were different from the classic inhibitive effect of heme on Abeta aggregation. Hydrogen Peroxide amyloid beta precursor protein Homo sapiens