Title : Sulfonylurea in combination with insulin is associated with increased mortality compared with a combination of insulin and metformin in a retrospective Danish nationwide study.

Pub. Date : 2015 Jan

PMID : 25205223






6 Functional Relationships(s)
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1 RESULTS: A total of 11,081 patients used SU + insulin and 16,910 used metformin + insulin. Sulfonylurea Compounds insulin Homo sapiens
2 SU + insulin was associated with higher mortality rates compared with metformin + insulin (76-126 vs 23 per 1,000 person-years). Sulfonylurea Compounds insulin Homo sapiens
3 In adjusted analyses, SU + insulin was associated with increased all-cause mortality (RR 1.81 [1.63, 2.01]), cardiovascular death (RR 1.35 [1.14, 1.60]) and the composite endpoint (RR 1.25 [1.09, 1.42]) compared with metformin + insulin. Sulfonylurea Compounds insulin Homo sapiens
4 In adjusted analyses, SU + insulin was associated with increased all-cause mortality (RR 1.81 [1.63, 2.01]), cardiovascular death (RR 1.35 [1.14, 1.60]) and the composite endpoint (RR 1.25 [1.09, 1.42]) compared with metformin + insulin. Sulfonylurea Compounds insulin Homo sapiens
5 Hypoglycaemia was more frequent with SU + insulin than with metformin + insulin (17-23 vs six events per 1,000 person-years) and was associated with increased mortality (RR 2.13 [1.97, 2.37]). Sulfonylurea Compounds insulin Homo sapiens
6 CONCLUSIONS/INTERPRETATION: In combination with insulin, the use of SUs was associated with increased mortality compared with metformin. Sulfonylurea Compounds insulin Homo sapiens