Title : Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine.

Pub. Date : 2014 Sep

PMID : 25202056






5 Functional Relationships(s)
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1 Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine. Fluorouracil ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens
2 ABCB6 expression enhanced resistance to 5-fluorouracil (5-FU), SN-38 and vincristine (Vcr) but not to arsenite. Fluorouracil ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens
3 ABCB6 expression enhanced resistance to 5-fluorouracil (5-FU), SN-38 and vincristine (Vcr) but not to arsenite. Fluorouracil ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens
4 Conversely, down-regulation of ABCB6 in KAS cells increased the sensitivity of KAS cells to 5-FU, SN-38 and Vcr, but not to arsenite. Fluorouracil ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens
5 Our findings suggest that ABCB6 is involved in 5-FU, SN-38 and Vcr resistance. Fluorouracil ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens