Title : Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene.

Pub. Date : 2014 Nov

PMID : 25199627






1 Functional Relationships(s)
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1 First, BaP-induced expression of key metabolic enzymes was analysed; expression levels of the activating CYP1A1 and CYP1B1 were increased, while the detoxifying enzymes UGT1A6 and UGT2B7 were significantly reduced by hypoxia. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens