Title : Metabolism of N-nitrosodimethyl- and N-nitrosodiethylamine by rat hepatocytes: effects of pretreatment with ethanol.

Pub. Date : 1989 Nov-Dec

PMID : 2519734






1 Functional Relationships(s)
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1 The inhibition patterns observed when an antibody inhibitory to cytochrome P-450j was added to microsomes derived from control and ethanol- and phenobarbital-pretreated rats conclusively demonstrate that NDMA and NDEA are preferentially metabolized by distinct isozymes of cytochrome P-450. Phenobarbital cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus