Title : Thiol-based regulation of glyceraldehyde-3-phosphate dehydrogenase in blood bank-stored red blood cells: a strategy to counteract oxidative stress.

Pub. Date : 2015 Mar

PMID : 25196942






1 Functional Relationships(s)
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1 RESULTS: At 21 days of storage, we demonstrated that cytosolic GAPDH undergoes temporary inactivation due to the formation of an intramolecular disulfide bond between the active-site Cys-152 and nearby Cys-156, a mechanism to rerouting glucose flux toward the pentose phosphate pathway. Pentosephosphates glyceraldehyde-3-phosphate dehydrogenase Homo sapiens