Title : β-Caryophyllene protects the C6 glioma cells against glutamate-induced excitotoxicity through the Nrf2 pathway.

Pub. Date : 2014 Oct 24

PMID : 25194788






4 Functional Relationships(s)
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1 beta-Caryophyllene protects the C6 glioma cells against glutamate-induced excitotoxicity through the Nrf2 pathway. caryophyllene NFE2 like bZIP transcription factor 2 Homo sapiens
2 Moreover, BCP per se induced the nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) which was reflected by improvement in the cellular GSH antioxidant system. caryophyllene NFE2 like bZIP transcription factor 2 Homo sapiens
3 Moreover, BCP per se induced the nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) which was reflected by improvement in the cellular GSH antioxidant system. caryophyllene NFE2 like bZIP transcription factor 2 Homo sapiens
4 Taken together, our results suggest that cytoprotective effects of BCP were mediated by the amelioration of cellular antioxidant responses via Nrf2 activation, which is, in part, dependent on cannabinoid receptor type 2 (CB2R) activation. caryophyllene NFE2 like bZIP transcription factor 2 Homo sapiens