Pub. Date : 2014 Sep 1
PMID : 25194025
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Morphine dependence in single enteric neurons from the mouse colon requires deletion of beta-arrestin2. | Morphine | arrestin, beta 2 | Mus musculus |
2 | However, morphine-treated colonic neurons from beta-arrestin2 knockout mice demonstrated increased excitability upon treatment with naloxone as assessed by change in rheobase, number of action potentials and input resistance. | Morphine | arrestin, beta 2 | Mus musculus |
3 | However, unlike the ileum, dependence to chronic exposure of morphine develops in colonic neurons from the beta-arrestin2 knockout mice. | Morphine | arrestin, beta 2 | Mus musculus |
4 | These studies corroborate the in-vivo findings of the differential role of neuronal beta-arrestin2 in the development of morphine tolerance/dependence in the ileum and colon. | Morphine | arrestin, beta 2 | Mus musculus |