Title : Morphine dependence in single enteric neurons from the mouse colon requires deletion of β-arrestin2.

Pub. Date : 2014 Sep 1

PMID : 25194025






4 Functional Relationships(s)
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1 Morphine dependence in single enteric neurons from the mouse colon requires deletion of beta-arrestin2. Morphine arrestin, beta 2 Mus musculus
2 However, morphine-treated colonic neurons from beta-arrestin2 knockout mice demonstrated increased excitability upon treatment with naloxone as assessed by change in rheobase, number of action potentials and input resistance. Morphine arrestin, beta 2 Mus musculus
3 However, unlike the ileum, dependence to chronic exposure of morphine develops in colonic neurons from the beta-arrestin2 knockout mice. Morphine arrestin, beta 2 Mus musculus
4 These studies corroborate the in-vivo findings of the differential role of neuronal beta-arrestin2 in the development of morphine tolerance/dependence in the ileum and colon. Morphine arrestin, beta 2 Mus musculus