Title : JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.

Pub. Date : 2014 Nov 13

PMID : 25193870






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In vivo treatment of leukemic mice with the JAK3 selective inhibitor tofacitinib reduced the white blood cell count and caused leukemic cell apoptosis. tofacitinib Janus kinase 3 Mus musculus