Title : Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells.

Pub. Date : 2014 Sep 30

PMID : 25193863






1 Functional Relationships(s)
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1 We provide evidence that mTORC1 inhibition by rapamycin results in engagement of a negative feedback regulatory loop in malignant medulloblastoma cells, involving phosphorylation of the eukaryotic translation-initiation factor eIF4E. Sirolimus eukaryotic translation initiation factor 4E Homo sapiens