Title : Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities.

Pub. Date : 2014 Nov

PMID : 25189993






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Exposure of tumor cells to JQ-101 significantly enhanced acetylation of p53 and histone H4K16 at known sites of SIRT1 deacetylation, validating SIRT1 as its cellular target. jq-101 tumor protein p53 Homo sapiens