Pub. Date : 2015 Feb
PMID : 25189466
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The results showed that leonurine significantly alleviated LPS-induced histopathological changes, downregulated the levels of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), upregulated the level of anti-inflammatory cytokine interleukin-10 (IL-10), and inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). | leonurine | prostaglandin-endoperoxide synthase 2 | Mus musculus |
| 2 | The results showed that leonurine significantly alleviated LPS-induced histopathological changes, downregulated the levels of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), upregulated the level of anti-inflammatory cytokine interleukin-10 (IL-10), and inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). | leonurine | prostaglandin-endoperoxide synthase 2 | Mus musculus |
| 3 | Therefore, the results demonstrated that leonurine could downregulate the expression of TNF-alpha, IL-6, iNOS, and COX-2 and upregulate the expression of IL-10 mainly by inhibiting the expression of TLR4 and the activation of NF-kappaB and the phosphorylation of p38, ERK, and JNK. | leonurine | prostaglandin-endoperoxide synthase 2 | Mus musculus |