Pub. Date : 2015 Feb
PMID : 25189466
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further study revealed that leonurine inhibited the expression of Toll-like receptor 4 (TLR4) and the activation of nuclear factor-kappaB (NF-kappaB) and the phosphorylation of p38, extracellular signal-regulated kinase (ERK), and Jun N-terminal kinase (JNK). | leonurine | mitogen-activated protein kinase 8 | Mus musculus |
| 2 | Further study revealed that leonurine inhibited the expression of Toll-like receptor 4 (TLR4) and the activation of nuclear factor-kappaB (NF-kappaB) and the phosphorylation of p38, extracellular signal-regulated kinase (ERK), and Jun N-terminal kinase (JNK). | leonurine | mitogen-activated protein kinase 8 | Mus musculus |
| 3 | Therefore, the results demonstrated that leonurine could downregulate the expression of TNF-alpha, IL-6, iNOS, and COX-2 and upregulate the expression of IL-10 mainly by inhibiting the expression of TLR4 and the activation of NF-kappaB and the phosphorylation of p38, ERK, and JNK. | leonurine | mitogen-activated protein kinase 8 | Mus musculus |