Title : Nitric oxide as a mediator of estrogen effects in osteocytes.

Pub. Date : 2014

PMID : 25189390






2 Functional Relationships(s)
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1 Moreover, we found that 17beta-estradiol protects osteocytes against apoptosis via the NO/cGMP signaling pathway: type II PKG mediates estradiol-induced activation of the prosurvival kinases Erk and Akt, whereas type I PKG contributes to prosurvival signaling by directly phosphorylating and inactivating the cell death protein BAD. Estradiol mitogen-activated protein kinase 1 Homo sapiens
2 Moreover, we found that 17beta-estradiol protects osteocytes against apoptosis via the NO/cGMP signaling pathway: type II PKG mediates estradiol-induced activation of the prosurvival kinases Erk and Akt, whereas type I PKG contributes to prosurvival signaling by directly phosphorylating and inactivating the cell death protein BAD. Estradiol mitogen-activated protein kinase 1 Homo sapiens