Title : Sources of superoxide/H2O2 during mitochondrial proline oxidation.

Pub. Date : 2014

PMID : 25184115






2 Functional Relationships(s)
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1 Even with combinations of substrates and respiratory chain inhibitors designed to minimize the contributions of other sites and maximize any superoxide/H2O2 production from proline dehydrogenase itself, there was no significant direct contribution of proline dehydrogenase to the observed H2O2 production. Hydrogen Peroxide proline dehydrogenase 1 Homo sapiens
2 Thus proline oxidation by proline dehydrogenase drives superoxide/H2O2 production, but it does so mainly or exclusively by providing anaplerotic carbon for other mitochondrial dehydrogenases and not by producing superoxide/H2O2 directly. Hydrogen Peroxide proline dehydrogenase 1 Homo sapiens