Title : Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture.

Pub. Date : 2015 Feb

PMID : 25183402






1 Functional Relationships(s)
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1 Structure-activity relationship analysis showed that CYP2B6 and CYP3A4 inducers are bulky lipophilic molecules with a higher number of heavy atoms and a lower number of hydrogen bond donors. Hydrogen cytochrome P450 family 2 subfamily B member 6 Homo sapiens