Pub. Date : 2014 Dec 28
PMID : 25179905
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human colon cancer HCT116 cells. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 2 | These 2-MeO-E2-induced cellular changes, except for G2/M arrest, appeared to be more apparent in the presence of p53. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 3 | These results show that among 2-MeO-E2-induced apoptotic events, including prometaphase arrest, up-regulation of Bax level, down-regulation of Bcl-2 level, activation of both Bak and Bax, and mitochondria-dependent caspase activation, the modulation of Bax and Bcl-2 levels is the target of the pro-apoptotic action of p53. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |