Title : Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.

Pub. Date : 2014 Nov 1

PMID : 25177796






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns(3)P-binding PX (phox homology) and FYVE domains. Phosphatidylinositols phosphatidylinositol 3-kinase catalytic subunit type 3 Homo sapiens
2 The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns(3)P-binding PX (phox homology) and FYVE domains. Phosphatidylinositols phosphatidylinositol 3-kinase catalytic subunit type 3 Homo sapiens
3 The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns(3)P-binding PX (phox homology) and FYVE domains. Phosphatidylinositols phosphatidylinositol 3-kinase catalytic subunit type 3 Homo sapiens
4 The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns(3)P-binding PX (phox homology) and FYVE domains. Phosphatidylinositols phosphatidylinositol 3-kinase catalytic subunit type 3 Homo sapiens
5 The first is produced through phosphorylation of PtdIns by Vps34 at the endosome. Phosphatidylinositols phosphatidylinositol 3-kinase catalytic subunit type 3 Homo sapiens