Title : Sterigmatocystin-induced oxidative DNA damage in human liver-derived cell line through lysosomal damage.

Pub. Date : 2015 Feb

PMID : 25176419






1 Functional Relationships(s)
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1 A statistically significant increase in AO fluorescence intensity was observed in cells treated with STC (1.5, 3 and 6 muM) for 1 h. The DNA strand breaks induced by STC were almost prevented in cells pretreated with NH(4)Cl (10 mM) and NAC (10 mM) for 1 h. Our results thus indicated that STC exerts genotoxic effects on HepG2 cells, most likely through oxidative stress and lysosomal leakage. Ammonium Chloride synuclein alpha Homo sapiens