Pub. Date : 2014 Nov
PMID : 25173565
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RARgamma-C-Fos-PPARgamma2 signaling rather than ROS generation is critical for all-trans retinoic acid-inhibited adipocyte differentiation. | Tretinoin | retinoic acid receptor gamma | Homo sapiens |
| 2 | Inhibition of RARgamma, but not RARalpha, blocked ATRA-induced reduction of PPARgamma2 expression. | Tretinoin | retinoic acid receptor gamma | Homo sapiens |
| 3 | ATRA induced a profound interaction between RARgamma and C-Fos protein, reflected by Co-IP results. | Tretinoin | retinoic acid receptor gamma | Homo sapiens |
| 4 | RARgamma inhibitor significantly suppressed ATRA-inhibited DNA binding activity of C-Fos to PPARgamma2 promoter, indicating that downregulation of C-Fos activity mediated activation of RARgamma-exerted reduction of PPARgamma2 expression and thus inhibition of adipocyte differentiation induced by ATRA. | Tretinoin | retinoic acid receptor gamma | Homo sapiens |
| 5 | RARgamma inhibitor significantly suppressed ATRA-inhibited DNA binding activity of C-Fos to PPARgamma2 promoter, indicating that downregulation of C-Fos activity mediated activation of RARgamma-exerted reduction of PPARgamma2 expression and thus inhibition of adipocyte differentiation induced by ATRA. | Tretinoin | retinoic acid receptor gamma | Homo sapiens |
| 6 | RARgamma inhibitor significantly suppressed ATRA-inhibited DNA binding activity of C-Fos to PPARgamma2 promoter, indicating that downregulation of C-Fos activity mediated activation of RARgamma-exerted reduction of PPARgamma2 expression and thus inhibition of adipocyte differentiation induced by ATRA. | Tretinoin | retinoic acid receptor gamma | Homo sapiens |
| 7 | RARgamma inhibitor significantly suppressed ATRA-inhibited DNA binding activity of C-Fos to PPARgamma2 promoter, indicating that downregulation of C-Fos activity mediated activation of RARgamma-exerted reduction of PPARgamma2 expression and thus inhibition of adipocyte differentiation induced by ATRA. | Tretinoin | retinoic acid receptor gamma | Homo sapiens |