Pub. Date : 2014
PMID : 25171128
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARgamma pathway. | caryophyllene | cannabinoid receptor 2 (macrophage) | Mus musculus |
| 2 | Recently, the plant metabolite beta-caryophyllene was shown to selectively bind to CB2 receptor and act as a full agonist. | caryophyllene | cannabinoid receptor 2 (macrophage) | Mus musculus |
| 3 | The use of the CB2 antagonist AM630 or the PPARgamma antagonist GW9662 significantly reversed the protective effects of beta-caryophyllene on APP/PS1 mice. | caryophyllene | cannabinoid receptor 2 (macrophage) | Mus musculus |
| 4 | CONCLUSION: These results demonstrate that the anti-inflammatory effect of the sesquiterpene beta-caryophyllene involves CB2 receptor activation and the PPARgamma pathway and suggest beta-caryophyllene as an attractive molecule for the development of new drugs with therapeutic potential for the treatment of AD. | caryophyllene | cannabinoid receptor 2 (macrophage) | Mus musculus |