Title : Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition.

Pub. Date : 2014

PMID : 25169527






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Silibinin caused G2/M phage arrest accompanied by a decrease in CDK1 and Cyclin B1 at protein and mRNA levels.. Silybin cyclin dependent kinase 1 Homo sapiens
2 CONCLUSIONS: These results suggest that silibinin inhibits the proliferation of MGC803 cells, and it induces apoptosis and causes cell cycle arrest by down-regulating CDK1, cyclinB1, survivin, Bcl-xl, Mcl-1 and activating caspase 3 and caspase 9, potentially via the STAT3 pathway. Silybin cyclin dependent kinase 1 Homo sapiens