Pub. Date : 2015 Feb
PMID : 25168245
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Here we show that the phosphorylation of nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2) by c-Jun N-terminal kinase (JNK) signaling stimulates ceramide generation and apoptosis and provide evidence for a signaling mechanism that integrates stress- and cytokine-activated apoptosis in vertebrate cells. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Here we show that the phosphorylation of nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2) by c-Jun N-terminal kinase (JNK) signaling stimulates ceramide generation and apoptosis and provide evidence for a signaling mechanism that integrates stress- and cytokine-activated apoptosis in vertebrate cells. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | The JNK inhibitor SP600125 blocked the phosphorylation and activation of nSMase1, which in turn blocked ceramide signaling and apoptosis. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | In addition, the depletion of MAPK8/9 or SMPD2 by RNAi knockdown decreased ceramide generation and stress- and cytokine-induced apoptosis in Jurkat cells. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Therefore the phosphorylation of nSMase1 is a pivotal step in JNK signaling, which leads to ceramide generation and apoptosis under stress conditions and in response to cytokine stimulation. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |