Title : Theoretical insights into the reductive metabolism of CCl4 by cytochrome P450 enzymes and the CCl4-dependent suicidal inactivation of P450.

Pub. Date : 2014 Oct 21

PMID : 25164482






1 Functional Relationships(s)
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1 It was found that under anaerobic conditions, the substrate CCl4 might undergo one or two subsequent one-electron reductions to generate different reactive metabolites, trichloromethyl radical ( CCl3) and dichlorocarbene (:CCl2) respectively. dichlorocarbene C-C motif chemokine ligand 2 Homo sapiens