Pub. Date : 2014 Oct
PMID : 25149566
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To better understand the mechanisms and molecular range of such ligand selectivity, we expressed the mouse eugenol OR (mOR-EG) in HEK293T cells together with Galpha15 to monitor activation of the phospholipase-C (PLC) signaling pathway and/or Galphaolf to monitor activation of the adenylate cyclase (AC) signaling pathway, resulting in intracellular Ca(2+) release and/or Ca(2+) influx through a cyclic nucleotide-gated channel, respectively. | Eugenol | olfactory receptor family 5 subfamily D member 18 | Mus musculus |
| 2 | Of 17 reported mOR-EG ligands tested, including eugenol, its analogs, and structurally dissimilar compounds (mousse cristal, nootkatone, orivone), some equally activated both signaling pathways, some differentially activated both signaling pathways, and some had no noticeable effect even at 1-5mM. | Eugenol | olfactory receptor family 5 subfamily D member 18 | Mus musculus |