Pub. Date : 2014
PMID : 25147816
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment. | Hyaluronic Acid | hyaluronan synthase 3 | Homo sapiens |
| 2 | Overexpression of HAS3 increased hyaluronan synthesis in BxPC-3 pancreatic cancer cells. | Hyaluronic Acid | hyaluronan synthase 3 | Homo sapiens |
| 3 | In vivo, overexpression of HAS3 led to faster growing xenograft tumors with abundant extracellular hyaluronan accumulation. | Hyaluronic Acid | hyaluronan synthase 3 | Homo sapiens |
| 4 | In conclusion, hyaluronan accumulation by HAS3 favors pancreatic cancer growth, at least in part by decreasing epithelial cell adhesion, and PEGPH20 inhibits these changes and suppresses tumor growth. | Hyaluronic Acid | hyaluronan synthase 3 | Homo sapiens |