Pub. Date : 2014
PMID : 25147596
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Subanesthetic isoflurane reduces zymosan-induced inflammation in murine Kupffer cells by inhibiting ROS-activated p38 MAPK/NF-kappaB signaling. | Zymosan | mitogen-activated protein kinase 14 | Mus musculus |
| 2 | Moreover, ISO attenuated ZY-induced p38 mitogen-activated protein kinase (MAPK) activation partly by scavenging reactive oxygen species (ROS); the interregulation that ROS activated p38 MAPK followed by NF-kappaB activation was crucial for the ZY-induced inflammatory responses in KCs. | Zymosan | mitogen-activated protein kinase 14 | Mus musculus |
| 3 | Moreover, ISO attenuated ZY-induced p38 mitogen-activated protein kinase (MAPK) activation partly by scavenging reactive oxygen species (ROS); the interregulation that ROS activated p38 MAPK followed by NF-kappaB activation was crucial for the ZY-induced inflammatory responses in KCs. | Zymosan | mitogen-activated protein kinase 14 | Mus musculus |
| 4 | These results suggest that ISO ameliorates ZY-induced inflammatory responses in murine KCs by inhibiting the interconnected ROS/p38 MAPK/NF-kappaB signaling pathways. | Zymosan | mitogen-activated protein kinase 14 | Mus musculus |