Pub. Date : 2015 Jul
PMID : 25138434
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 9 | Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 10 | Moreover, both N-acetylcysteine and the superoxide dismutase mimetic, MnTBAP, reversed quercetin-induced intracellular reactive oxygen species production, ERK activation, and subsequent cell death. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 11 | In conclusions, our results indicated that quercetin induced cell death of HL-60 cells in vitro and in vivo through induction of intracellular oxidative stress following activation of an ERK-mediated apoptosis pathway. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |