Title : Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release. A novel effect on free arachidonic acid levels in human synovial cells.

Pub. Date : 1989 Nov 1

PMID : 2512925






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1 Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release. Diclofenac interleukin 1 alpha Homo sapiens
2 The inhibitory effects of two non-steroidal anti-inflammatory drugs (NSAIDS), diclofenac and indomethacin, on interleukin-1 (IL-1)-induced changes in arachidonic acid (AA) release and prostaglandin E2(PGE2) production by human synovial cells was investigated. Diclofenac interleukin 1 alpha Homo sapiens
3 Both diclofenac and indomethacin potently inhibited IL-1 alpha-induced PGE2 release, with IC50 values of 1.6 +/- 0.02 nM and 5.5 +/- 0.1 nM, respectively. Diclofenac interleukin 1 alpha Homo sapiens
4 These results suggest that whilst at nanomolar concentrations, diclofenac and indomethacin can inhibit IL-1 alpha-induced PGE2 output, at micromolar concentrations an effect on free AA levels is also evident. Diclofenac interleukin 1 alpha Homo sapiens